The exact role of different isoforms of PKC in cardiac disease is still ambiguous; taking into consideration that the PKC family of enzymes includes three classes and 12 isoforms, and that PKC isoforms have four structurally conserved domains (C1–C4) and five variable domains (V1–V5) [78] accordingly we can say that the selectivity of the PKC targeting drugs is an issue that can cause unacceptable on-target and off-target effects [79]. The gene discussed is PRRT2; the disease is heart disorder.