ROCK2 and heart disorder: Based on the fact that many ROCK-II inhibitors were identified to be potent and selective in addition to the fact that the role of ROCK-II in the pathogenesis of heart disease is very well established, we suggest that the next step should emphasize on bridging the gap between the previously synthesized ROCK-II inhibitors and their efficacy in treating hypertensive and heart-related conditions in animal models and clinical studies.