Figure 1 summarizes the most important kinase targets that have been previously reported as kinase targets for heart disease treatment [6]. The most important are ROCK II [7,8], Ca+2 CaMK IIδ [9–11], protein kinase C (PKC) [12,13], PI3K [14], GSK-3β, FAK and MAPKs [15]. Here, PRRT2 is linked to heart disorder.