In the case of NNV, we have demonstrated that the innate CMC or NCC activity of head-kidney (the main hematopoietic tissue in fish) leucocytes (HKLs) from NNV-infected specimens was increased against xenogeneic tumor cells in both gilthead seabream and European sea bass, but mainly in the last one, and that the gene expression of nccrp1, involved in leucocyte recognition of the target cell and binding, was mainly up-regulated in the head-kidney and brain from European sea bass and slightly in the gilthead seabream specimens16. Here, SLC12A3 is linked to neoplasm.