Comparing our data with single- cell transcriptomic data62 revealed that all genes identified as EC specific compared to CF (except CAV2, which only displayed a moderate increase) also showed at least several 10-fold upregulation in ECs at the proteomic level (Supplementary Data 8).SMCs contain the same muscle-contracting proteins as cardiac cells but do not have troponin. This evidence concerns the gene CAV2 and cystic fibrosis.