In the context of another research project that will be described in detail elsewhere, we discovered that the overexpression of the Myc oncogene in Adeno-Cre-treated renal cell cultures derived from Trp53fl/fl mice (Myc/Trp53∆/∆) causes the formation of spheres and these cells form tumours in allograft assays (Supplementary Fig. 4c–f). Here, MYC is linked to neoplasm.