HMGB1 and atherosclerosis: Further in-depth investigation on DHI’s therapeutic effects is required to explore other identified critical functions such as leukocyte migration, angiogenesis and thrombosis, key pathways such as atherosclerosis signaling, HMGB1 signaling and LXR/RXR activation, important upstream regulators such as PPARG, TGFB1, IL6 and VEGFA, all of which had predicted by our network analysis.