HMGB1 and early-onset autosomal dominant Alzheimer disease: (5) Other top-ranked diseases and functions that are influenced by DH, such as dementia and Alzheimer’s disease, leukocyte migration, HMGB1 and HIF 1α signalings and LXR/RXR activation showed in Fig. 3, provide new clinical indications for DH and DHI that warrant future in-depth study.