Interestingly, Ramp3, a gene implicated in type-2 diabetes pathology and VSMC contraction40, is present near the enhancer-associated lncRNA lnc-Ang383 (Fig. 5b) and Ramp3 was induced 3–6 h post AngII treatment (Fig. 5g). Here, RAMP3 is linked to type 2 diabetes mellitus.