AGT and obesity due to melanocortin 4 receptor deficiency: Notably, these regions in the human genome harbor known GWAS/SNPs for AngII-related CVD disease/traits, including abdominal aortic aneurysms (AAAs), atrioventricular conduction, coronary heart disease, diastolic blood pressure, glucose homeostasis traits, inflammatory skin disease, obesity-related traits, pulmonary function decline, systolic blood pressure, and Type 1/2 diabetes (Supplementary Table 2).