ESM1 and hypertensive disorder: We examined two representative AngII-upregulated genes, namely, endothelial cell-specific molecule1 (Esm1) and Sprouty Homolog2 (Spry2), that are involved in VSMC growth, proliferation and inflammation32,33, and one AngII-downregulated gene, AngII Receptor Type1a (Agtr1a), which mediates AngII signaling involved in hypertension and CVD34.