As shown by GSEA, this mTORC1 gene signature correlated with a PC gene signature comprising increased splenic MZ B-cell expression of gene products regulating cell adhesion (COCH, CADM1, and CD58), cell proliferation (CCNB2 and TYMS), antibody glycosylation (FUT8), and PC differentiation and survival (LGALS1, BHLHE41, ZBTB32, and KLF10) (Fig. 1h, Supplementary Fig. 1f, and Supplementary Data 1). This evidence concerns the gene CD58 and pachyonychia congenita.