We found that the six cell lines with a high fraction of cells carrying extra centrosomes (>30%) invariably lost E-cadherin protein expression, and this was independent of breast cancer subtype (Fig. 7, A and B), although higher levels of centrosome amplification are associated with basal cell lines, as previously shown (D’Assoro et al., 2002; Denu et al., 2016). Here, CDH1 is linked to breast cancer.