In comparison with our study, findings regarding CRP, fibrinogen, D-dimer, vWF and cTnT reported in earlier studies of younger adults were similar; a few previous studies reported that they did not find an association of time of day with CRP,23 D-dimer24 and vWF.25 In one study, the variation in CRP, fibrinogen, D-dimer and vWF attributable to time of day was minimal.6 Literature on cTnT is scarce; one small previous study of repeated measures in seven participants with type 2 diabetes reported a decrease in cTnT between 08:00 and 20:00.26 This evidence concerns the gene VWF and type 2 diabetes mellitus.