Several studies reported that metabolic syndrome is a better predictor of CVD risk compared with FRS because of high dependency of FRS to age, underestimation of cardiovascular disorders in young ages, and lack of coverage several prominent features of metabolic syndrome such as obesity, hyper-triglyceridemia, and elevated high CRP levels [20, 21]; however, two previous US reports [22, 23] showed that FRS is more predictive for CVD risk than metabolic syndrome. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.