A marked increase in Nox2 protein level in reactive microglia was also documented in experimental models of PD based on combined administration of minimally toxic dose of LPS and alpha-synuclein oligomers [102], intraperitoneal injection of paraquat [103] or 6-OHDA [104, 105], on exposure to atmospheric ultrafine particles considered as a potential environmental risk factor for PD [106] as well as with aging and traumatic brain injury known to increase the risk of parkinsonism [107–109]. This evidence concerns the gene CYBB and Parkinson disease.