Mutations in genes encoding proteins of the endosomal/lysosomal system, vacuolar protein sorting-35 (VPS35), type 5 P-type ATPase ATP13A2, and glucocerebrosidase (GBA1) are also associated with PD [16] and represent a link between autophagy-lysosome function and neurodegeneration. The gene discussed is GBA1; the disease is Parkinson disease.