EZH2 and neoplasm: Numerous studies report that knockdown of EZH2 by siEZH2 or function suppression by DZNep induce GBM growth inhibition [13–15] and EZH2 is well recognized to take part in multiple tumor processes such as cell cycle [14], proliferation [16], apoptosis [16], invasion and mobility [16], GBM stem cell differentiation and maintenance [17, 18], tumor angiogenesis [19], etc. Our previous study demonstrates that miR-138 effectively inhibits GBM cell proliferation in vitro and tumorigenicity in vivo through directly blocking an EZH2-mediated signal loop [8].