IL4 and neoplasm: The classically activated microglia/macrophages, M1 phenotype, stimulate anti-tumor immune response through secretion of pro-inflammatory cytokines, such as IFN-gamma, IL1β, iNOS, etc., whereas the alternatively activated or M2 phenotypes promote tumor survival via producing anti-inflammatory cytokines like IL4, TGFβ, IL10, etc. [3].