When plants suffer from pest stress, a variety of defense proteins which inhibit the insect from producing digestive enzymes are produced to resist insect pests, including PR, proteinase inhibitors, chitinase and lectin [71, 72] and thereby destroy the insect’s normal digestive absorption functions, then disrupt their nutrient uptake and utilization, which could ultimately lead to malnutrition and inhibited growth of the insects [73]. This evidence concerns the gene TMEM37 and nutritional deficiency disease.