Recently, in a randomized double-blind, placebo-controlled trial which enrolled 174 patients with type 2 DKD across CKD stages 1 to 3, Han et al. [46] showed that add-on PTX at a dose of 1200 mg daily for 6 months reduced proteinuria and improved glucose control and insulin resistance, without decreasing serum TNF-α levels. The gene discussed is TNF; the disease is chronic kidney disease.