In line with the effectiveness of GnRH antagonist (cetrotide) therapy for control of frequency and severity of OHSS in high-risk women received GnRH-a induction protocol; Bonilla-Musoles et al. [16] reported that compared to controls, treatment with 3 mg cetrotide seems to be effective in the management of severe OHSS with significantly dropped E2 levels and faster peritoneal fluid regression as measured by US few days after treatment, and none of cetrorelix treated patients required paracentesis. The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.