Hosseini et al. [17] reported that the frequency of moderate and severe OHSS, hospitalization or acute care for OHSS and ascites tap rates were significantly lower with significantly higher patients' satisfaction with cetrotide than in control group and concluded that GnRH antagonist cetrotide seems to be an effective outpatient treatment with rapid onset activity and minimal side effects for the management of early OHSS. This evidence concerns the gene GNRH1 and ovarian hyperstimulation syndrome.