For prophylaxis against development of OHSS, multiple trials compared gonadotropin-releasing hormone (Gn-RH) agonist (GnRH-a) versus Gn-RH-antagonist (GnRH-ant) induction protocols wherein Kdous et al. [3] found GnRH-ant allows a higher flexibility in treatment, a lower dose of follicle stimulating hormone (FSH) was required and a shorter period of stimulation with no case of OHSS versus 3% with GnRH-a therapy. Here, GNRH1 is linked to ovarian hyperstimulation syndrome.