Various drugs were evaluated for the prevention or treatment of OHSS; experimentally, in rat model of OHSS, both myo-inositol and metformin reduced vascular endothelial growth factor (VEGF) and COX-2 expressions with decreased vascular permeability and blood E2 levels in the groups treated with myo-inositol or metformin compared to the OHSS group [6]. The gene discussed is PTGS2; the disease is ovarian hyperstimulation syndrome.