Cohort definitions varied slightly between studies, specifically regarding treatment of adenocarcinomas with NE differentiation, which were grouped with NEPCs in WCMC mCRPC, with adenocarcinomas in MDA xeno, and variably with either cohort depending on IHC status in UW mCRPC (grouped with NEPC when synaptophysin and chromogranin both positive). Here, SYP is linked to adenocarcinoma.