AR and adenocarcinoma: On the gene expression level, ARS scores were retained at levels similar to adenocarcinomas (fold-change > -0.5 and z-score > -1 relative to adenocarcinomas) in 5/16 (31%) SCPCs (Fig. 1), corresponding to the SCPCs clustering with adenocarcinomas in the meta-12 centroid profiles (Fig. 2), including both pure and mixed cases, and comprised of the SCPCs with robustly positive AR IHC (57912_S, 56107) and SCPCs with unknown AR status (56057, 57914, 57915).