With the aim of understanding the transcriptome expression changes pivotal to eBL development, we identified the aberrant expression of genes (such as ATM and NLK) and miRNAs (such as let-7 family members and miR-17~92 cluster members) that could endorse eBL lymphoma development and sustain survival of tumor cells in the presence of myc translocation. The gene discussed is NLK; the disease is lymphoma.