ASB9 and obesity due to melanocortin 4 receptor deficiency: Although there was no strong indication that TBX2, ASB9, IL17C, and ABCG4 were the causal variant of obesity in the population, studies showed that these genes may also be part of the multifactorial etiology of this complex condition as follows: (I) TBX2: The results of a prospective cohort on the associations of menarche-related genetic variants with pubertal growth in adolescents indicated that SNPs (rs757608) near TBX2 is associated with a rapid weight gain [94].