And it was reported that members of the phospholipase A2 (PLA2) family of enzymes, such as PLA2G1B [64], PLA2G5, and PLA2G2E [65], can serve a distinct role in generating active lipid metabolites, which can promote inflammatory metabolic diseases including obesity [66, 67]. Here, PLA2G1B is linked to obesity due to melanocortin 4 receptor deficiency.