Using the high confidence experimental and predicted IPA database, in the DLBCL patient group mainly STAT3, IL-8, p13k/AKT and TGF-B signaling pathways were identified to be potentially up regulated, while PTEN and p53 pathways to be potentially down-regulated (Fig F in S1 File). The gene discussed is CXCL8; the disease is diffuse large B-cell lymphoma.