Degradation of IKZF1 and IKZF3 by CRBN seems, however, to be myeloma specific, as other CRBN neosubstrates have been associated with different diseases, such as casein kinase 1 alpha (CK1α) in myelodysplastic syndromes with the deletion of chromosome 5q (Krönke et al., 2015). This evidence concerns the gene CRBN and plasma cell myeloma.