ALDH2 and Myocardial fibrosis: Activation of ALDH2 with the specific agonist Alda-1 could restrain the proliferation of CFs cultured with high glucose, reduce the release of ROS and 4-HNE protein expression, decrease oxidative stress overload as well as the expressions of collagen I and collagen III, reverse myocardial fibrosis, and attenuate CFs apoptosis.