When CFs were treated with high glucose and ALDH2 agonist Alda-1, ALDH2 activity and expression were increased while the collagen I and collagen III mRNA expressions were decreased, it suggested that Alda-1 promote the expression of ALDH2, and the increase of ALDH2 can reverse myocardial fibrosis. The gene discussed is ALDH2; the disease is Myocardial fibrosis.