The frequencies of CD3+CD8+IFNγ+ T cells after ZIKV infection that were restimulated ex vivo with DENV2-E4–12, DENV2-E7–15, and DENV2-NS3347–355 were 2.92 ± 0.18%, 0.56 ± 0.1%, and 0.55 ± 0.11%, respectively (two independent experiments, Supplementary Fig. 2a). This evidence concerns the gene IFNG and Zika virus infectious disease.