CD8A and Zika virus infectious disease: A study focusing on cross-reactive T cell responses in Ifnar1−/− HLA-transgenic mice has shown that prior DENV immunity alters immunodominance patterns of CD8+ T cell responses to subsequent ZIKV infection38, while another has demonstrated that passive transfer of DENV-immune plasma into naive Stat2−/− mice can enhance ZIKV infection and disease severity12.