Based on a published study demonstrating that CD8+ T cells can prevent DENV ADE44, the higher level of ZIKV in the serum of CD8+ T cell-depleted DENV2-immune mice relative to naive mice suggests that CD8+ T cells also might control the ADE induced by cross-reactive DENV Abs following ZIKV infection. This evidence concerns the gene CD8A and Zika virus infectious disease.