Re-expression of TRIM24WT* rescued p-STAT3 level (Fig. 7e), the protein and mRNA expression levels of ID1 (Fig. 7e, f), cell proliferation (Fig. 7g), colony formation in soft agar (Fig. 7h) and cell migration (Fig. 7i) upregulated by EGFRvIII in GBM cells, whereas re-expression of TRIM24-R193A/K195A* could not (Fig. 7e–i). The gene discussed is STAT3; the disease is glioblastoma.