To further assess which genes are co-upregulated by EGFR and TRIM24 in glioma cells, we identified 35 genes that were significantly reduced by TRIM24 knockdown and upregulated by EGFRvIII in LN229 GBM cells (fold change >2, p < 0.05; Fig. 5a). The gene discussed is TRIM24; the disease is central nervous system cancer.