To understand why TRIM24 is important for EGFR/EGFRvIII-driven glioma tumorigenesis, we performed transcriptome analysis in LN229 parental (LN229/P) and LN229/EGFRvIII (LN229/vIII) GBM cells transfected with an empty vector or TRIM24 shRNAs (LN229/vIII/shT24-1 and LN229/vIII/shT24-2) using RNA-seq. This evidence concerns the gene TRIM24 and glioblastoma.