Moreover, co-expression of p-EGFR and TRIM24 (Fig. 9b), co-expression of p-EGFR/H3K23ac, co-expression of TRIM24/H3K23ac or co-expression of TRIM24/p-STAT3 at high levels correlated with significantly shorter survival in patients with GBM (Supplementary Fig. 8). The gene discussed is TRIM24; the disease is glioblastoma.