Taken together, our data demonstrate that TRIM24 recruits STAT3 to chromatin in EGFR-driven glioma cells, which is dependent on H3K23ac association, thus providing evidence that TRIM24 binds with EGFR-upregulated H3K23ac, and then recruits STAT3 and stabilizes its interaction with chromatin. The gene discussed is EGFR; the disease is central nervous system cancer.