In conclusion, our findings identify TRIM24 as an oncogenic transcriptional co-activator in EGFR-driven GBM and also demonstrate a previously unknown signal relay by which H3K23ac/TRIM24 mediates EGFR stimulation of STAT3 activation, thereby enhancing the oncogenic activity of the EGFR/STAT3 pathway in human cancers. The gene discussed is STAT3; the disease is glioblastoma.