Most variants had the strongest effects in the persistent class and 3 variants showed consistent associations in ALSPAC and PIAMA: These were rs17881320 in STAT3, rs479844 near OVOL1, and rs6010620 in RTEL1. One variant (rs1057258) showed evidence in ALSPAC for association in the opposite direction to that reported previously for AD with the late-onset and early-onset-early-resolving classes (OR, 0.73, 95% CI, 0.57-0.93, P = .011, and OR, 0.80, 95% CI, 0.65-0.99, P = .039, respectively). Here, STAT3 is linked to Alzheimer disease.