In a multivariate analysis adjusting for treatment, tumor size, grade, ER, and HER2, the prognostic value of cytoplasmic raptor expression was observed to be significant when analyzing all patients (HR 1.43, 95% CI 1.00–2.06, p = 0.049), with a similar trend for systemically untreated patients (HR 1.47, 95% CI 0.93–2.33, p = 0.098). The gene discussed is ESR1; the disease is neoplasm.