The present study was performed to determine whether GalR1 is involved in galanin-induced antinociception in CeA in normal rats, and further to demonstrate the antinociceptive effects induced by intra-CeA injection of galanin in rats with neuropathy, as well as the galanin and GalR1 expression in CeA in normal rats and rats with neuropathy. Here, GAL is linked to neuropathy.