After c-KIT endocytosis by dasatinib and radotinib, it might be degraded by lysosomal processing, and lead to activation of the apoptotic pathway (Annexin V positive cells and Apaf-1 expression were increased) in c-KIT-positive AML cells (Figs 3 and 4; Supplementary Fig. 2 and 3). This evidence concerns the gene ANXA5 and acute myeloid leukemia.