Interestingly, roflumilast (similar to methylprednisolone) successfully limited Th2-associated airway inflammation and antigen-specific secretion of IL-4 and -13 from lymph node lymphocytes (see Supplementary Fig. S1d–f), suggesting the failure to suppress airway inflammation was restricted to Th17-dependent airway inflammation for both substances. The gene discussed is IL4; the disease is inflammation.