DLAT and primary biliary cholangitis: Serobiochemically, 90–95% of PBC patients are positive for anti-mitochondrial antibodies (AMAs), which predominantly recognize the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2) and, in some cases, the E2 subunit of branched chain 2-oxo-acid dehydrogenase (BCOADC-E2) and 2-oxo-glutarate dehydrogenase (OGDC-E2)1,11.