Moreover, death receptor 5 (DR5) expression on BECs contributes to common bile-duct ligation-induced cholestasis in mice, and DR5-mediated signaling is also indicated to be involved in the pathogenesis of human cholestatic diseases, such as primary sclerosing cholangitis and PBC29. The gene discussed is TNFRSF10B; the disease is sclerosing cholangitis.