We identified PMP22 point mutations in four out of 53 molecularly unassigned demyelinating CMT patients selected from 265 demyelinating CMT patients or 382 patients with all kinds of CMT, indicating that PMP22 point mutations are responsible for 1.5% (4/265) of demyelinating CMT and 1.0% (4/382) of total CMT in Taiwan. Here, PMP22 is linked to Charcot-Marie-Tooth disease.