For model 2, the research elements included AFP, hepatitis B virus infection status and PKM2 expression, and the analysis results showed that AFP (HR = 1.523, P = 0.032) and PKM2 expression (HR = 3.020, P = 0.001) were independent prognostic factors for RFS in patients with cirrhotic HCC; PKM2 expression (HR = 3.812, P = 0.008) was an independent prognostic factor for RFS in patients with non-cirrhotic HCC. This evidence concerns the gene AFP and hepatitis B virus infection.