PKM and hepatocellular carcinoma: Of course, our research is limited, and further studies should investigate the specific mechanism of PKM2 signalling in cirrhosis HCC and non-cirrhosis HCC progression, such as the ways of PKM2 converted to distinct tetrameric and dimeric states, the specific mechanism of dimeric PKM2 entry into the nucleus and the relation of PKM2 and oncogenic signaling pathways.