Next, we characterized a collection of colon cancer xenografts and found that SW1222-derived tumors showed a polarized distribution of nuclear β-catenin, FRA1, CK20, and GLUT1, while HCT116 colon cancer xenografts showed more diffuse marker expression and lack of differentiation gradients (Fig. 1d). The gene discussed is FOSL1; the disease is malignant colon neoplasm.