Depletion of macrophages reduced tumor growth also in some glioma models (Quail & Joyce, 2017; Zhai et al, 2011), and interestingly, small molecule inhibition of CSF‐1R was found to dramatically block tumor growth and progression by downregulating markers of M2‐like polarization of TAMs in a proneural model of glioblastoma (Pyonteck et al, 2013). This evidence concerns the gene CSF1R and central nervous system cancer.