In previous publications, patients with FARS2 deficiency were noted to have either (i) early-onset epileptic encephalopathy [8], [9], [10], [11], [12], (ii) autosomal recessive hereditary spastic paraplegia [13], [14], or (iii) juvenile onset refractory epilepsy [15]. This evidence concerns the gene FARS2 and hereditary spastic paraplegia.