CLEC5A and atherosclerosis: To further investigate molecular mechanisms which affected MDL-1 expression in the progression and regression of atherosclerosis and demonstrate what we observed in mouse models and polarized BMDMs, we used several pathophysiological agents implicated in plaque progression (i.e. ox-LDL and hypoxia) or regression (i.e. HDL) to stimulate macrophages and detected MDL-1 expression in vitro [26, 27].