Moreover, investigations on 9P21.3 coronary artery disease (CAD) risk locus of human macrophages exhibited remarkable differences in gene expression including CCL-8, CCL-2 and MDL-1 between myocardial infarction patients and controls [19], which suggested macrophage MDL-1 might be associated with CAD progression. This evidence concerns the gene CCL2 and coronary artery disorder.