These functions of MDL-1 might partly explain what we have observed in this study, which significant increased MDL-1 expression is found on M1 proinflammatory macrophage subtype, PBMCs from significant CAD patients and associated with inflammatory chemokine (e.g. MCP-1) production and atherosclerotic plaque progression. The gene discussed is CLEC5A; the disease is coronary artery disorder.