The observation of increased YKL-40 in the cerebellum of 22 L infected mice allowed to speculate that (22 L)-infected cultured organotypic cerebellar slices (COCS), which recapitulate most of the morphological and neuropathological hallmarks associated with prion infection and serve as an excellent ex vivo tool for the study of prion pathogenesis [55, 62], could recapitulate the alterations in YKL-40 expression observed in in vivo scrapie models. Here, CHI3L1 is linked to scrapie.