Our study supports the notion that Stat3 function as a tumor suppressor, but do not back the notion that Stat3 can also function as oncogene in lung tumor development because our results revealed that cell proliferation, Cyclin D and cyclin E expression were all decreased when Stat3 was more activated (Y705 phosphorylation) in the tumors from our Hdac7+/−/K-Ras mice. This evidence concerns the gene CCNE1 and neoplasm.