All these results from studies of mouse genetics, human lung cancer cell lines and clinic lung cancer patients strongly suggest that HDAC7 play an oncogenic role in human lung cancer, but our conclusion is contradictory to a previous report by Osada, et al., claiming that high HDAC7 mRNA level in human lung tumors was correlated to good progonosis [4]. The gene discussed is HDAC7; the disease is lung carcinoma.