We found that in the Lenti-Cre infected group, Hdac7 mutant dramatically inhibited lung cancer development, however, in Lenti-Cre-2A-dnStat3 infected group, neither tumor number on lung surface (Fig. 5b) nor tumor burden (Fig. 5c) were significantly different between Hdac7+/−/K-Ras mice and control K-Ras mice. The gene discussed is KRAS; the disease is lung carcinoma.