Our study showed that not only exogenous Stat3 and Hdac7 proteins expressed in 293T cells (Fig. 6f and g) were co-immunoprecipitated reciprocally, but also endogenous STAT3 and HDAC7 proteins in human lung cancer cells and mouse lung tumors from control K-Ras mice (Fig. 6d and e). This evidence concerns the gene KRAS and lung carcinoma.