CRHR1 and hypertensive disorder: The SKAT-O analysis for 376 rare variants revealed associations between glucocorticoid receptor (Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1, FDR 0.17) and the extreme phenotype as well as between pre-HTN and Corticotropin Releasing Hormone Receptor 1 (CRHR1) (FDR 0.20) and Corticotropin Releasing Hormone Receptor 2 (CRHR2) (FDR 0.20) (Table 4).