Combined rare and common variant analyses exhibited 8 associations: BAD (FDR 0.04), APOB (FDR 0.12), Cystathionine-Beta-Synthase (CBS) (FDR 0.12) and Solute Carrier Organic Anion Transporter Family Member 4C1 (SLCO4C1) (FDR 0.14) with dyslipidemia; BAD (FDR 0.003) and NR3C1 (FDR 0.15) with the extreme phenotype; and CRHR1 (FDR 0.14) and CRHR2 (FDR 0.14) with pre-HTN (Table 4). The gene discussed is CRHR2; the disease is hypertensive disorder.