First, neutrophils, monocytes, and platelets have been reported to promote tumor development via different mechanisms [17–19], whereas lymphocytes are essential for the elimination of cancer cells [20], and serum albumin is the main plasma protein used to indicate the nutritional status of the host; this may partly explain why elevated NLR, elevated PLR, low LMR, and low PNI were associated with poor prognosis in CRC. The gene discussed is ALB; the disease is cancer.