In our study we were able for the first time to show that RNY1, RNY3 and RNY4 could very good discriminate between the normal and tumor tissue with a maximal AUC of 0.863 (RNY3), and to a lesser extent between muscle-invasive and not-muscle-invasive tumors (maximal AUC 0.780 for RNY3). This evidence concerns the gene RNY4 and neoplasm.