Since the RP-score may incorporate either direct or indirect PPI information, genes such as EGFR and AKT1 that are positioned upstream of the NSCLC signaling cascades, which includes EGFR, RAS/MAPK and AKT/PI3K pathways, gained higher scores than other genes positioned downstream of the NSCLC signaling cascades. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.