The methylation profile of the genes was similar between BCP ALL, control and TCF3-PBX1 rearrangement carriers, except the north-shore part of the CpG island located near the transcription start site of the TCF3 gene shows hypermethylation in control group with respect to the BCP ALL patients (genome-wide adjusted p<0.05) (Fig 12). This evidence concerns the gene TCF3 and acute lymphoblastic leukemia.