Other genes with predominantly positive associations included RNF43 and MACF1 in COAD; CASP8 in HNSC; PBRM1 (a chromatin remodeler), SETD2 (a histone methyltransferase), and BAP1 (a histone deubiquitinating enzyme) in KIRC; SETD2 in kidney renal papillary cell carcinoma (KIRP); SPOP in prostate adenocarcinoma (PRAD); PIK3CA in STAD; and PTEN in uterine corpus endometrial carcinoma (UCEC). The gene discussed is PBRM1; the disease is gastric adenocarcinoma.