Although the recent clinical trial targeting LOXL2 inhibition (ClinicalTrials.gov NCT01769196) was halted early because of a lack of efficacy (Raghu et al., 2017), the present study suggests that targeting LOXL1 in IPF might be as important as targeting LOXL2. Here, LOXL2 is linked to idiopathic pulmonary fibrosis.