MECOM and ocular melanoma: OM penetrance ranges from ∼30% in the BpifA1-null mouse mutant (BpifA1 encodes the innate immune response protein BPI fold-containing family A member 1) (Bartlett et al., 2015) to ∼80% in a mouse carrying a point mutation at the immunomodulatory Mecom (MDS1 and EVI1 complex) locus (Parkinson et al., 2006).