FBXO11 and ocular melanoma: FBXO11 was initially associated with OM in an Australian cohort (Rye et al., 2011), with nominal evidence of association, and then replicated in a UK cohort (Bhutta et al., 2017) and a US cohort (Segade et al., 2006), albeit at different polymorphisms at FBXO11. Data from the Fbxo11 mouse model (see below) suggest that a mutation in Fbxo11 perturbs transforming growth factor (TGF)-β signalling in the middle ear.