Goblet cell hyperplasia is also seen with OM in mice carrying a null mutation in the following genes: the chromatin-remodelling gene Chd7 (chromodomain-helicase-DNA-binding protein 7), the transcriptional co-activator Eya4 (EYA transcriptional coactivator and phosphatase 4), the immunomodulatory gene Tgif (TGFB induced factor homeobox 1) and the structural protein Sh3pxd2b (SH3 and PX domains 2B) (Tian et al., 2012; Depreux et al., 2008; Tateossian et al., 2013; Yang et al., 2011). The gene discussed is TGIF1; the disease is ocular melanoma.