In one study, the severity of LV defects in the thoracic duct of a mouse model [connexin-37 (Cx)37−/−;Cx43+/−; see further details in Vascular valve disorders, below] was shown to correlate with the onset of chylothorax and postnatal death (Kanady et al., 2011). This evidence concerns the gene GJA4 and Chylothorax.