CDC42 and injury: These are further modulated by the activities of small guanosine triphosphate (GTP)ases, particularly the Rho family of GTPases, such as the Ras homolog gene family member A (RhoA), cell division cycle 42 (Cdc42) and Rac1 and transcriptionally regulated by KLF2 as shown in case of acute lung injuries in rodent models [18].