However, FK886 completely blocked the protective effects of P7C3-A20 on PTX-induced mechanical allodynia and IENF degeneration (Figure 5B and C and Figure 5—figure supplement 1C), suggesting that NAMPT activity is required for the neuroprotective effect of P7C3-A20 on PTX-induced peripheral neuropathy. Here, NAMPT is linked to peripheral neuropathy.