As is typical of CIPN (Cata et al., 2006; Dougherty et al., 2004; Nahman-Averbuch et al., 2011), PTX treatment also produced marked peripheral neuropathy evidenced by prolonged changes in the sensitivity to mechanical, cold and heat stimuli, by prolonged degeneration of IENFs, and by increased expression of the neuronal injury marker, ATF3, in the DRG. Here, ATF3 is linked to peripheral neuropathy.