At the same time, ZAP70‐high B‐CLLs do not exhibit such obvious abnormalities but differ from normal B‐cells in expression of CD79B (which is common for all CLL samples) together with differences in SYK and LYN mRNA, which expression is similar to CD5‐high B‐cells and slightly downregulated compared to normal CD5‐low B‐lymphocytes. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.