Moreover, the ZAP70‐low B‐CLL cells demonstrated a lower mRNA expression of SHP1, CD79B, SYK, and LYN compared to the normal CD5‐high and CD5‐low B‐cells (P < 0.05 for all groups), thus demonstrating a unique mRNA profile that differs from any other type of B‐cells. This evidence concerns the gene CD5 and B-cell chronic lymphocytic leukemia.