BCR and B-cell chronic lymphocytic leukemia: In contrast, the ZAP70‐high group displays an overexpression of all kinases involved in BCR signalosome formation together with the downregulation of SHP1 inhibiting phosphatase gene (Fig. 6), which leads to the activation of the NFkB and AKT survival pathways and the expression of antiapoptotic proteins, such as mcl‐1 and bcl‐2, which have been shown to act as crucial players in defective apoptosis in B‐CLL cells 48, 49.