We have further evaluated the efficacy of molecular‐targeted drugs, including the EGFR‐TKI, MET‐TKI, and the tropomyosin‐related kinase (TRK)‐TKI, in our brain tumor models, in comparison to their efficacy in extracranial tumor models, such as subcutaneous tumors, peritoneal carcinomatosis, and liver metastasis models. The gene discussed is TPM3; the disease is brain neoplasm.